Substance P: The Multifaceted Role of a Neuropeptide in Physiology and Pathology
Endocrinology Diagnostics
Substance P Summary:
Molecular Structure:
- 11-amino acid neuropeptide
- From TAC1 gene
- Binds neurokinin-1 receptor (NK1R)
Key Functions:
- Pain signal transmission
- Inflammatory response regulation
- Neurotransmitter/neuromodulator
Pain Mechanisms:
- Amplifies pain signal sensitivity
- Involved in acute/chronic pain
- Triggers inflammatory responses
Inflammatory Involvement:
- Impacts asthma
- Increases vascular permeability
- Influences rheumatoid arthritis
- Affects digestive system disorders
Neuropsychiatric Connections:
- Linked to stress responses
- Potential depression biomarker
- May influence schizophrenia development
Therapeutic Potential:
- NK1R antagonist medications
- Pain relief strategies
- Biomarker diagnostic applications
- Exploring novel treatment pathways
Research Focus:
- Pain management
- Inflammation control
- Mental health interventions
- Neuropeptide signaling pathways
Significance: Complex neuropeptide with multisystem physiological impacts.
Suitable ELISA Kits
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